From Dire Wolves to Giant Birds: The Technical Evolution of De-Extinction Methods
Colossal Biosciences has achieved what many considered impossible just months ago: the successful birth of three dire wolves, marking the first time an extinct mammalian species has been brought back to life through genetic engineering. Now, the Dallas-based biotech company is expanding its de-extinction pipeline to include New Zealand's giant moa, a 12-foot-tall flightless bird that vanished 600 years ago. The transition from recreating ancient mammals to reviving extinct birds presents dramatically different technical challenges that highlight the evolving sophistication of de-extinction science.
The dire wolf achievement, announced earlier this year, relied on ancient DNA extracted from a 13,000-year-old tooth and 72,000-year-old skull. Scientists used CRISPR gene-editing technology ...